![]() The historical roots of meta-analysis can be traced back to 17th century studies of astronomy, while a paper published in 1904 by the statistician Karl Pearson in the British Medical Journal which collated data from several studies of typhoid inoculation is seen as the first time a meta-analytic approach was used to aggregate the outcomes of multiple clinical studies. 4.6 Weak inclusion standards lead to misleading conclusions.4.5 Comparability and validity of included studies.4.4 Problems arising from agenda-driven bias.4.3 Problems related to the statistical approach.4.2 Problems related to studies not reporting non-statistically significant effects.4.1 Publication bias: the file drawer problem.3.3 Validation of meta-analysis results.3.2.3.3 Generalized pairwise modelling framework. ![]()
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